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A2M Arthritis Injection Treatment

What is A2M (Alpha 2 Macroglobulin)?

A2M molecules repairing arthritisA2M is a naturally occurring molecule that is already found in your blood. While it is naturally occurring and protective of the human body it is difficult for it to travel to joint or disc space because of its large size and complex nature. The A2M molecule has two binding areas that capture proteases, destructive enzymes. After binding with those destructive enzymes the A2M molecules natural are eliminated through normal body processes.

What does A2M treat?

A2M molecule injections are used throughout the bodies joints for several reasons. Pain from overuse such as tennis elbow or golfers elbow, chronic pain stemming from arthritis, osteoarthritis are a few to name. The main reasons to use A2M injection therapy are:

  • To reduce or eliminate inflammation and pain
  • To prevent further breakdown of tissue
  • To restore joint health
  • To prevent or delay costly or invasive surgeries

a2m healing power

How does the A2M injection work?

A2M injections are an in office procedure that general takes no more than 1 hour. We put you in one of our treatment rooms in a comfortable positions where we can initially drawn your blood. One of our trained staff with the oversight of a doctor will draw around 160 cc’s of blood from your arm. Your drawn blood is than spun down with our in office centrifuge for about 10 minutes.The spinning of your blood helps separate out two different types of plasma, red and yellow. Red plasma is traditionally used in PRP injections which have more inflammatory side effects than A2M. Once the plasma is separate out it goes through and additional filtration process to be able to isolate the yellow plasma. This yellow plasma, several cc’s, will be used to inject a concentrated does of A2M back into the problem joints. If you are suffering pain in several areas we are usually able to treat more than one location. 

Patients generally feel no inflammation or pain after the injection. More importantly they often feel improved and mobility in the injected joint the same day it happens. The time frame of relief can vary based on age, severity and several other factors but it is not uncommon to feel relief for several months or longer when does with proper therapy.


Are you a candidate for A2M treatment?

candidate for A2M injectionsUsing the biomarker, Fibronectin-Aggrecan Complex (FAC), we are able to test prior to receiving the A2M injection for the presence of this protein. It is associated with painful inflammation. Often times you are already in enough pain or it is obvious that the injection is the right route to go. But this free test is a great option if you are unsure which treatment route to take. Please contact us today to schedule your free biomarker test to see if A2M injections are right for you.

A2M injections are a safe and effective treatment alternative to partial/total joint replacement. At Prestige Orthopedics and Sports Medicine, a New York based orthopedic speciality group, we make every attempt to treat your issues without surgical intervention. Find out today if A2M injections can help get you back to a pain free life.


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The founding mission of Prestige Orthopaedics & Sports Medicine is to provide safer, more effective and quicker recoveries with less pain and unrivaled service

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